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Mild toxicity arises after a single dose of around 150 mg/kg body weight, whereas severe toxicity is associated with a single dose of greater than 500 mg/kg

Chamoun Z, Mann RK, Nellen D, von Kessler DP, Bellotto M, Beachy PA, et al

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Methods Enzymol 400:395400 Hirrlinger J, Dringen R (2010) The cytosolic redox state of astrocytes: maintenance, regulation and functional implications for metabolite trafficking